The reigning Super Bowl champion Kansas City Chiefs and Pittsburgh Steelers both entered Sunday undefeated.
Only the Steelers left that way.
Derek Carr threw three touchdown passes and Josh Jacobs ran for two more scores as the Las Vegas Raiders won 40-32 at Kansas City.
Rookie receiver Chase Claypool scored four touchdowns in the Steelers' 38-29 victory over the Philadelphia Eagles. The second-round pick from Notre Dame scored on a 2-yard run and on catches of 32, 5 and 35 yards.
In other early-afternoon games, Carolina beat Atlanta 23-16, the Los Angeles Rams defeated Washington 30-10, Baltimore trounced Cincinnati 27-3 and Houston beat Jacksonville 30-14.